There are 2 anti idiotype vaccines in the pipeline.
mAb 1A7 by Dr. Alice Yu and team.
mAb1A7 is an anti-idiotype antibody directed against a murine anti-GD2, 14G2a, and in effect, mimics the GD2 antigen. Yu et al conducted a clinical trial of mAb 1A7 as a surrogate GD2 vaccine in 31 patients with high risk neuroblastoma who achieved first or subsequent responses (74). There were no systemic toxicities seen with subcutaneous injections given periodically over two years, but only local reactions, transient fever in four patients and serum sickness in one. All patients generated anti-mAb1A7 and their immune sera displayed CDC and ADCC activities. Sixteen of 21 patients who enrolled during first remission had no evidence of disease progression at a median of 6 years, while only 1 of 10 patients in second remission remains progression free. These findings indicated that mAb1A7 vaccine has little toxicity, is effective in inducing biologically active anti-GD2, and may be useful in controlling MRD (75) (unpublished data from Yu et al).
There is also the slightly newer anti idiotype vaccine by Dr. Holger Lode and team
Importantly, patients vaccinated with 1A7 showed little side effects which underlines the suitability of such a vaccine for clinical application. To provide unrestricted access for clinical development in Europe, we recently generated and characterized a murine anti-Id Ab ganglidiomabwhich paratopes mimic GD2.
In summary, we describe the generation and characterization of a new chimeric anti-Id Abganglidiximab used as a protein vaccine to induce humoral immunity against NB in mice. Our results are an important baseline for further development of new anti-Id Ab-based vaccination approaches against GD2-expressing malignancies
Having an accessible vaccine is at the top of the list for parents. Current immunotherapy approaches only have an effect while children are treated, they do not have any lasting protective effect. A vaccine could protect children for many years and avoid countless relapses.
I was wondering if anyone knows
Are there any open trials (phase 1/2) for an anti idiotype vaccine?
Is there anything parents can do to help drive innovation around either vaccines?
What happened with 1A7? Are there any phase 2 trials, now that toxicity levels are clear?