In the past few years SIOPEN have been running a trial for the effects of Long Term Infusion for immunotherapy using CH 14.18.
The researchers’ analysis of pain assessment scores and use of intravenous morphine indicated that long-term infusion of ch14.18/CHO was associated with reduced pain, compared with data previously reported for children treated with short-term infusion. The patients also had lower frequencies of grade 3 or higher adverse events in the long-term infusion group vs the short-term infusion group, except for equal frequencies in vomiting.
“In our study, by changing the method of antibody delivery from short-term infusion to long-term infusion, we observed an impressive reduction of on-target [pain] and off-target [inflammation] side effects, while maintaining effective drug levels over the entire treatment period, as assessed in a variety of bioassays, demonstrating the immune-modulatory effect of ch14.18/CHO and its potency to mediate destruction of neuroblastoma cells constantly over a period of 6 months,”
So it looks like LTI
Increases the amount of time you are in hospital from 5 to 10 days per immunotherapy cycle
Is just as effective as STI (short term infusion)
Does anyone who participated in the trial have any stories for us? How painful is immunotherapy under STI? Is this something I should explore?