In a recent publication by Dr. Ruth Ladenstein for ASCO, it was published that CH14.18 is actually causing tumours to shrink.
This was highlighted in the talk by Prof. Holger Lode at ANR 2016.
Overall response to immunotherapy was 51%.
Out of 50 kids with a partial response prior to immunotherapy 16 moved on to complete response. (in frontline use of STI)
Initially when we were diagnosed the common prevailing knowledge in the field was that immunotherapy only acts against microscopic disease. These results are quite astounding.
This raises the question about the place of immunotherapy in NB treatment. Should we be giving immunotherapy drugs earlier? In quite a few hospitals in the US oncologists have started giving immunotherapy during induction chemo (in trials) which seems related.
I think this is quite important information for parents to have, especially if you are being held off on using immunotherapy due to the NB being in in partial response.