I can’t speak to the science of whether ch14.18 requires that kind of caution. But I can tell you that my son participated in two different ch14.18-based trials, two years apart, at two different U.S. hospitals, and we were never advised to use the thick gloves.
Ours (LCCH in Australia) treats ch14.18 as cytotoxic… as well as ISO/RA… But I think it’s more from a ‘we don’t fully know all the side effects of handing this’ safety perspective than it actually being cytotoxic.